huji Koret School of Veterinary Medicine

Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem

Nahum Yehuda Shpigel, BVSc., Ph.D

Associate Professor - Food Production Veterinary Medicine
School of Veterinary Medicine The Robert H. Smith Faculty of Agricultural, Food & Environment, The Hebrew University of Jerusalem.

Office Address:
P.O.Box 12, Rehovot 76100, Israel
Phone: +972-(0)8-9489534
Fax: +972-(0)8-9467940
Cell: +972 (0)522 851383
Email Address:

Laboratory Website

Special interests

Virulence mechanism and host-pathogen interaction
Crohn’s Disease and other Inflammatory Bowel Diseases

Professional Experience and Qualifications

Microbiology and immunology of bacterial diseases
Mastitis in dairy animals
Veterinary herd health and internal medicine in food animals


Bacterial diseases in food animals, Gastroenterology in food animals,
Cardiovascular diseases in food animals, Urinary diseases in food animals,
Clinical examination of food animals, Clinical pharmacology in food animals



Mycobacterium paratuberculosis in Crohn's disease, Innate immune response in the mammary gland, Virulence mechanisms of mammary pathogenic Escherichia coli, Virulence mechanisms and host-pathogen interaction of Enterohemorrhagic E. coli (EHEC)



  • Member of the Curriculum Committee of The Koret School of Veterinary Medicine
  • Member of the Planning and Development Committee of the Koret School of Veterinary Medicine
  • Head of the Section of Food Producing Animals, The Koret School of Veterinary Medicine


Membership in Scientific organizations

- American Association of Bovine Practitioners (AABP)
- National Mastitis Council, USA (NMC)
- Israeli Veterinary Medical Association
- Israeli Society for Microbiology (ISM)
- International Association for Paratuberculosis
- Member and Diplomate of The European College of Bovine Health Management
- American Society for Microbiology


Selected Recent Publications

1. Erez GONENS, Shlomo NEDVETZKIC, David NAORC, N. Y. SHPIGELPI (2008) CD44 is highly expressed on milk neutrophils in bovine mastitis and plays a role in their adhesion to matrix and mammary epithelium. Veterinary Research 39:29-38.
2. N.Y. ShpigelPI, Sharon ElazarS and Ilan RosenshineC (2008) Mammary Pathogenic Escherichia coli. Current Opinion in Microbiology 11:60-65.
3. Navit Grinberg,S Sharon Elazar,S Ilan Rosenshine,C and N.Y. ShpigelPI (2008) β-hydroxybutyrate Abrogates Bovine Neutrophil Extracellular Traps Formation and Bactericidal Activity Against Mammary Pathogenic Escherichia coli. Infection and Immunity 76:2802-2807.
4. M. van Straten,S N.Y. ShpigelC, and M. FrigerPI (2008) Analysis of Daily Body Weight Measurements of High Producing Dairy Cows in the First 120 Days of Lactation: Time Series Analysis, Characteristics and "Standard" Body Weight Curves. Journal of Dairy Science 91:3353-3362.
5. L GolanS, A Livneh-KolS, E GonenS, S YagelC, I RosenshineC, N.Y. ShpigelPI (2009) Mycobacterium avium paratuberculosis invade human small intestinal goblet cells and elicit inflammation. Journal of Infectious Diseases 199:350-354.
6. Eyal Klement, N.Y. Shpigel, Ran D. Balicer, Gad Baneth, Itamar Grotto, Nadav Davidovitch (2009) “One Health”, from science to policy: examples from the Israeli experience. Veterinaria Italiana 45:45-53.
7. Morick D S, Baneth GC, Avidor BC, Kosoy MYC, Mumcuoglu KYC, Mintz D S, Eyal OC, Goethe RC, Mietze AC, Shpigel NC, Harrus SPI. (2009) Detection of Bartonella spp. in wild rodents in Israel using HRM real-time PCR. Veterinary Microbiology (in press)
8. M. van Straten,S N.Y. ShpigelC, and M. FrigerPI (2009) Associations among patterns in daily body weight, body condition scoring, and reproductive performance in high-producing dairy cows. Journal of Dairy Science 92:4365-4374.
9. M. van Straten,S M. FrigerPI and N.Y. ShpigelC (2009) Events of Elevated Somatic Cell Counts in High Producing Dairy Cows are Associated with Daily Body Weight Loss in Early Lactation. Journal of Dairy Science 92:4386-4394.
10. Elazar S,S Gonen E,S Livneh-Kohl A, Rosenshine I,C Shpigel NY.PI (2010) Neutrophil recruitment in endotoxin-induced murine mastitis is strictly dependent on mammary alveolar macrophages. Veterinary Research 2009 Oct 14;41(1):10.
11. GolanS, E GonenS, A Livneh-KolS, S YagelC, I RosenshineC, N.Y. ShpigelPI (2010) Enterohemorrhagic Escherichia coli O157:H7 induce hemorrhagic colitis, epithelial damage and formation of attaching and effacing lesions, in the human and bovine intestinal xenograft model. Submitted for publication.
12. Elazar S,S Gonen E,S Livneh-Kohl A, Rosenshine I,C Shpigel NY.PI (2010) Essential role of neutrophils but not mammary alveolar macrophages in a murine model of acute Escherichia coli mastitis. Submitted for publication.




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