huji Koret School of Veterinary Medicine

Robert H. Smith Faculty of Agriculture, Food and Environment,
The Hebrew University of Jerusalem

Shimon Harrus, DVM, Ph.D

Dipl. ECVCP
Professor, Veterinary Internal Medicine.

Office Address:
P.O. Box 12, Rehovot 76100, Israel
Phone: +972-(0)8-9489022; 972-(0)3-9688546
Fax: +972-(0)8-9467940
Email Address: shimon.harrus@mail.huji.ac.il


Special interests

Infectious diseases, vector-borne diseases, vector-pathogen-host interactions, zoonoses, rickettsial diseases, ehrlichiosis, bartonellosis.


Professional Experience and Qualifications

Diplomate of the European College of Veterinary Clinical Pathology (ECVCP).

Specialist (Israeli specialization), Veterinary Internal Medicine of Companion Animals.


Teaching

Small Animal Internal Medicine, Physiology, Parasitology, Pharmacology.

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Research

Rickettsioses, Ehrlichiosis, Bartonelosis, other vector-borne diseases, vector-pathogen-host interactions.

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Service

  • Director, Koret School of Veterinary Medicine.
  • Member, Board of Governors, Veterinary Teaching Hospital, Hebrew University.
  • Member, Board of Governors, The Authority for Animal Facilities, Hebrew University.
  • Member, Central Reception Committee, Hebrew University.
  • Member, State Council for Animal Experimentation.
  • Member, Editorial Board, Israel Journal of Veterinary Medicine.
  • Member, Scientific Council, Israel Veterinary Medical Association.
  • Member, Executive Committee, The European Association of Establishments for Veterinary Education (EAEVE).

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International interests

Veterinary education, Infectious diseases, Veterinary clinical pathology.

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Membership in Scientific organizations

- Israel Veterinary Medical Association.
- American Society for Rickettsiology.
- European College of Veterinary Clinical Pathology.
- Israel Society for Parasitology, Protozoology & Tropical Diseases.
- European Society of Veterinary Internal Medicine.
- Israel Society for Microbiology.

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Selected Publications

Harrus, S., Kenny, M., Miara, L., Aizenberg, I., Waner, T. and Shaw, S. (2004). Comparison of simultaneous splenic sample PCR with blood sample PCR for iagnosis and treatment of experimental Ehrlichia canis infection. Antimicrob. Agents Chemother. 48:4488-4490.

Harrus, S. and Baneth, G. (2005). Drivers for the emergence and reemergence of vector-borne protozoal and rickettsial organisms. Int. J. Parasitol. 35:1309-1318.

Bauer, O., Baneth, G., Eshkol, T., Shaw, S. and Harrus, S. (2006). Poly-genic detection of Rickettsia felis in cat fleas (Ctenocephalides felis) from Israel. Am. J. Trop. Med. Hyg. 74:444-448.

Harrus, S., Lior, Y., Ephros, M., Grisaru-Soen, G., Keysary, A., Strenger, C., Jongejan, F., Waner, T., Baneth, G. (2007). Rickettsia conorii in humans and dogs: a seroepidemiological survey of two rural villages in Israel. Am. J. Trop. Med. Hyg. 77:133-135.

Shipov, A., Klement, E., Reuveni-Tager, L., Waner, T. and Harrus, S. 2008. Prognostic indicators for canine monocytic ehrlichiosis. Vet. Parasitol. 153:131-138.

Baneth, G., Harrus, S., Ohnona,F.S., and Schlesinger Y. 2009. Longitudinal quantification of Ehrlichia canis in experimental infection with comparison to natural infection. Vet. Microbiol. 136:321-5.

Or, M., Samish, M., Waner, T. and Harrus, S. 2009. Attenuation of Ehrlichia canis by multiple-passages in 2 different cultures. Clin. Microbiol. Infect. 15:74-75.

Morick, D., Osinga, N., Gruys, E. and Harrus, S. 2009. Identification of a Bartonella species in the harbor seal (Phoca vitulina) and in seal lice (Echinophtirius horridus). Vector Borne Zoonotic Dis. 9:751-753.

Harrus, S., Kahila Bar-Gal, G., Golan, A., Elazari-Volcani, R., Kosoy, M., Morick, D., Avidor, B., Baneth, G. 2009. Isolation and genetic characterization of a genotype closely related to Bartonella tribocorum and Bartonella elizabethae in Israeli wild rats. Am. J. Trop. Med. Hyg. 81:55-58.

Morick, D., Baneth, G., Avidor, B., Kosoy, M. Y., Mumcuoglu, K. Y., Mintz, D.C, Eyal, O., Goethe, R., Mietze, A., Shpigel, N., Harrus, S. 2009. Detection of Bartonella spp. in wild rodents in Israel using HRM real-time PCR. Vet. Microbiol. 139:293-297.

Peleg, O., Baneth, G., Eyal, O., Inbar, J. and Harrus S. 2009. The use of chimeric DNA/RNA primers in quantitative PCR for the detection of Ehrlichia canis and Babesia canis Appl. Environ. Microbiol. 19:6393-6398.

Ohad, D. G., Morick, D., Avidor, B., Harrus, S. 2009. Molecular detection of Bartonella henselae and Bartonella koehlerae from aortic valves of Boxer dogs with infective endocarditis. Vet. Microbiol. 141:182-185.

Peleg, O., Baneth, G., Eyal, O., Inbar, J. and Harrus, S. 2010. Multiplex real time qPCR for the detection of Ehrlichia canis and Babesia canis vogeli. Vet. Parasitol. 173:292-299.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Shenbrot, G. I., Kosoy, M. Y., Harrus, S. 2010. Bartonella genotypes in fleas (Insecta: Siphonaptera) collected from rodents in the Negev Desert, Israel. Appl. Environ. Microbiol. 76:6864-6869.

Harrus, S., Waner, T. 2011. Diagnosis of canine monocytotropic ehrlichiosis: An overview. Vet. J. 187:292-296.

Harrus, S., Perlman-Avrahami, A., Mumcuoglu, K. Y., Morick, D., Baneth, G. 2011. Molecular detection of Rickettsia massiliae, Rickettsia sibirica mongolitimonae and Rickettsia conorii israelensis in ticks from Israel. Clin. Microbiol. Infect. 17:176-180.

Harrus, S., Perlman-Avrahami, A., Mumcuoglu, K. Y., Morick, D., Eyal. O., Baneth, G. 2011. Molecular detection of Ehrlichia canis, Anaplasma bovis, Anaplasma platys, Candidatus Midichloria mitochondrii and Babesia canis vogeli in ticks from Israel. Clin. Microbiol. Infect. 17:459-463.

Mietze, A., Morick, D. , Köhler, H., Harrus, S., Nolte, I., Goethe, R. 2011. Combined MLST and AFLP typing of Bartonella henselae isolated from cats reveals new sequence types and suggests clonal evolution. Vet. Microbiol. 148:238-245.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gottlieb, Y., Harrus, S. 2011. Investigation of Bartonella acquisition and transmission in Xenopsylla ramesis fleas (Siphonaptera: Pulicidae). Mol. Ecol. 20:2864-2870.

Mylonakis, M. E., Ceron, J. J., Leontides, L., Siarkou, V. I., Martinez, S., Tvarijonaviciute, A., Koutinas, A. F., Harrus, S. 2011. Serum acute phase proteins in naturally-occurring canine monocytic ehrlichiosis (Ehrlichia canis). J. Vet. Int. Med. 25:811-817.

Lalzar, I.S, Harrus, S.C, Mumcuoglu, K.C, and Gottlieb, Y. 2012. Composition and seasonal variation of Rhipicephalus turanicus and Rhipicephalus sanguineus bacterial communities. Appl. Environ. Microbiol. 78:4110-6

Rudoler, N. Baneth, G. Eyal, O. van Straten, M. Harrus, S. (2012). Evaluation of an attenuated strain of Ehrlichia canis as a vaccine for Canine Monocytic Ehrlichiosis. Vaccine, 31: 226-233.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gottlieb, Y. and Harrus, S. (2013). Transmission dynamics of Bartonella species OE 1-1 in Sundevall's Jirds (Meriones crassus). Appl. Environ. Microbiol. 79:1258-1264.

Theodorou, K., Mylonakis, M., Siarkou, V., Leontides, L., Koutinas, A., Koutinas, C., Kritsepi- Konstantinou, M., Batzias, G., Flouraki, E., Eyal, O., Kontos, V., Harrus, S. (2013). Efficacy of rifampin in the treatment of experimental acute canine monocytic ehrlichiosis. J. Antimicrob. Chemoth. 68:1619-26.

Kamani, J., Baneth, G., Mumcuoglu, K. Y., Waziri, N. E., Eyal, O., Guthmann, Y., Harrus, S.(2013). Molecular detection and characterization of tick-borne pathogens in dogs and ticks from Nigeria. PLoS Neglect. Trop. Dis. 7(3):e2108. doi: 10.1371.

Amram, E., Freed, M., Khateb, N., Mikula, I., Blum, S., Spregser, J., Sharir, B., Ozeri, R., Harrus, S. Lysniansky, I. (2013). Multiple locus variable number tandem repeat analysis of Mycoplasma bovis isolated from local and imported cattle. Vet. J. 197:286-290.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gutiérrez, R., Fielden, L. J., Gottlieb, Y. and Harrus, S. (2013). Effects of Bartonella on feeding and reproductive performance of fleas. Appl. Environ. Microbiol. 79:3438-3443.

Waner, T. and Harrus, S. (2013). Canine monocytic ehrlichiosis - from pathology to clinical manifestations. Isr. J. Vet. Med. 68:12-18.

Kleinerman, G., Baneth, G., Mumcuoglu, K. Y., van Straten, M,, Berlin, D., Apanaskevich, D. A., Abdeen, Z., Nasereddin, A., Harrus, S. (2013). Molecular detection of Rickettsia africae, Rickettsia aeschlimannii and Rickettsia sibirica mongolitimonae in camels and Hyalomma spp. ticks from Israel. Vector Borne Zoonotic Dis. 13:851-856.

Kamani, J., Morick, D., Morick, Mumcuoglu, K. Y., Harrus, S. (2013). Prevalence and diversity of Bartonella species in commensal rodents and ectoparasites from Nigeria, West Africa. PLoS Neglect. Trop. Dis. 7(5):e2246.

Gutiérrez, R., Morick, D., Gross, I., Winkler, R., Abdeen, Z., Harrus, S. (2013). Bartonella in domestic and stray cats from Israel – Comparison of Bacterial cultures and HRM real time PCR as diagnostic methods. Vector Borne Zoonotic Dis. 13:857-864.

Morick, D., Krasnov, B. R., Khokhlova, I. S., Gutiérrez, R., J., Gottlieb, Y. and Harrus, S. (2013). Vertical non-transovarial transmission of Bartonella in fleas. Mol. Ecol. 18:4747-4752.

Mylonakis, M. E., Xenoulis, P. G., Theodorou, K., Siarkou, V.I., Steiner, J. M., Harrus, S., Leontides, L., Rallis, T., Suchodolski, J. S., Koutinas, C., Koutinas, A. F. (2014). Serum canine pancreatic lipase immunoreactivity in experimentally-induced and naturally-occurring canine monocytic ehrlichios (Ehrlichia canis). Vet. Microbiol. 169:198-202.

Lerner, U., Amram, E., Ayling, R. D., Mikula, I., Gerchman, S., Harrus, S., Teff, D., Yogev, D., Lysniansky, I. (2014). Acquired resistance to the 16-membered macrolides tylosin and tilmicosin by Mycoplasma bovis. Vet. Microbiol. 168:365-371.

Gutiérrez, R., Morick, D., Cohen, C., Hawlena, H., and Harrus, S. (2014). The effect of ecological and temporal factors on the composition of Bartonella infection in rodents and their fleas. The ISME Journal 8:1598-1608.

Kamani, J., Baneth, G., Mitchell, M., Mumcuoglu, K. Y., Gutiérrez, R., Harrus, S. (2014). Bartonella species in bats (Chiroptera) and bat flies (Nycteribiidae) from Nigeria, West Africa. Vector Borne Zoonotic Dis. 14:625-632. .

Gutiérrez, R., Cohen, L., Morick, D., Mumcuoglu, K. Y., Harrus, S. and Gottlieb, Y. (2014). Identification of different Bartonella species in the cattle tail louse Haematopinus quadripertusus and in cattle blood. Appl. Environ. Microbiol. 80:5477-5483. .

Nasereddin, A., Risheq, A., Harrus, S., Azmi, K., Ereqat, S., Baneth, G., Salant, H., Mumcuoglu, K.Y., Z. Abdeen. (2014). Bartonella species in fleas from Palestinian territories: Prevalence and genetic diversity. J. Vector Ecol. 39:261-270. .

Waner, T., Nachum-Biala, Y., Harrus, S. (2014). Evaluation of a commercial in-clinic point-of-care polymerase chain reaction test for Ehrlichia canis DNA in artificially infected dogs. Vet. J. 202:618-21. .

Amram, E., Mikula, I., Schnee, C., Ayling, R. D., Nicholas, R. A. J., Rosales, R. S., Harrus, S., Lysnyansky, I. (2015). Presence of 16S rRNA gene mutations associated with acquired decreased susceptibility to tetracycline in Mycoplasma bovis. Antimicrob. Agents Chemother. 59:796-802. .

Baneth, G., Harrus, S. Gal, A., Aroch, I. (2015). Canine vector-borne co-infections: Ehrlichia canis and Hepatozoon canis in the same host monocytes. Vet. Parasitol. 208:30-34. .

Sainz, Á., Roura, X., Miró, G., Estrada-Peña, A., Kohn, B., Harrus, S., Solano-Gallego, L. (2015). Guideline for veterinary practitioners on canine ehrlichiosis and anaplasmosis in Europe. Parasit. Vectors. 8:75. doi: 10.1186/s13071-015-0649-0. .

Gutiérrez, R., Krasnov, B. R., Morick, D., Gottlieb, Y. Khokhlova, I. S. Harrus, S. (2015). Bartonella infection in rodents and their flea ectoparasites – An overview. Vector Borne Zoonotic Dis. 15:27-39. .

Sofer, S., Gutiérrez, R., Morick, D., Mumcuoglu, K., Harrus, S. Molecular detection of zoonotic bartonellae (B. henselae, B. elizabethae and B. rochalimae) in fleas collected from dogs in Israel. Med. Vet. Entomol. doi: 10.1111/mve.12116. .

Kamani, J., Baneth, G., Apanaskevich, D. A., Mumcuoglu, K. Y., Harrus, S. (2015). Molecular detection of Rickettsia aeschlimannii in Hyalomma spp. ticks from camels (Camelus dromedarius) in Nigeria, West Africa. Med. Vet. Entomol. 29:205-209. .

Rzotkiewicz, S., Gutiérrez, R., Krasnov, B. R., Morick, D., Khokhlova, I. S., Nachum-Biala, Y., Baneth, G., Harrus, S. (2015). Novel evidence suggests that a "Rickettsia felis-like" organism, is an endosymbiont of the desert flea, Xenopsylla ramesis. Mol. Ecol. 24:1364-1373. .

Theodoro, K., Leontides, L., Siarkou, V. I., Petanides, T., Tsafas, K., Harrus, S., Mylonakis, M. E. Synovial fluid cytology in experimental acute canine monocytic ehrlichiosis (Ehrlichia canis). Vet. Mic. 177:224-227. .

Rudoler, N., Harrus, S., Martinez-Subiela, S., Tvarijonaviciute, A., van Straten, M., Ceron, J., Baneth, G. (2015). Comparison of the acute phase protein and antioxidant responses in dogs vaccinated against canine monocytic ehrlichiosis and naive-challenged dogs. Parasit. Vectors. 8:175. doi: 10.1186/s13071-015-0798-1. .

Harrus, S. (2015). Perspectives on the pathogenesis and treatment of canine monocytic ehrlichiosis (Ehrlichia canis). Vet. J. doi: 10.1016/j.tvjl.2015.04.027. .

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